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The criminalisation of sex work in Botswana, Namibia, and South Africa leaves sex workers vulnerable to sexual and physical abuse, as well as extortion, from law enforcement officers such as police and border guards. Human rights violations and a lack of safe and supportive working conditions render sex workers particularly vulnerable to HIV. These are some of the findings of this report on the health and rights challenges confronted by female, male, and transgender sex workers in Botswana, Namibia, and South Africa.